Synthesis and activities of derivatives of magnolol and honokiol
10.11665/j.issn.1000-5048.20170505
- VernacularTitle:厚朴酚与和厚朴酚衍生物的合成及其生物活性
- Author:
Xiaodi LI
1
;
Xinglong GUO
;
Rongji DAI
;
Fang LYU
;
Lin CONG
;
Yulin DENG
Author Information
1. 北京理工大学生命学院
- Keywords:
magnolol;
honokiol;
derivative;
Alzheimer's disease;
Aβ protein inhibitor;
synthesis;
activity
- From:
Journal of China Pharmaceutical University
2017;48(5):536-542
- CountryChina
- Language:Chinese
-
Abstract:
Based on the chemical structures of magnolol and honokiol,a series of small molecular derivatives were designed for the treatment of Alzheimer's disease.Through the Discovery Studio,five compounds (6a-6e) exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds.Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T.The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L,which deserves further research.
