Germ-free animal as a model to study the role of gut microbiota in the pathogenesis of rheumatoid arthritis
10.3969/j.issn.1005-4847.2017.06.015
- VernacularTitle:基于无菌动物研究肠道微生物与类风湿关节炎发病相关性
- Author:
xia Cai HUI
1
;
hua Ben ZENG
;
fei Xiao LIU
;
Hong WEI
;
fei Yong FANG
Author Information
1. 第三军医大学西南医院中西医结合科与风湿免疫中心
- Keywords:
Germ-free animal;
Gut microbiome;
Rheumatoid arthritis;
Immunity;
Animal models
- From:
Acta Laboratorium Animalis Scientia Sinica
2017;25(6):667-670,675
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between intestinal microbiome and host growth and development, immunity, metabo-lism and other aspects is very close. But the complex interaction between intestinal microbiota and host is still largely un?known. At present, germ?free animal models have become an important tool for exploring the interaction between intestinal microbiome and host. Many studies used germ?free animal models to explore the role of gut microbiome in host metabolism, the development of the immune system, including the role of gut microbiome in the pathogenesis and prognosis of autoim?mune diseases. It has been found that intestinal microbiome as one of the environmental factors may be involved in the pathogenesis of rheumatoid arthritis, but its causal relationship is unknown. This paper will review the correlation between the intestinal microbiota and pathogenesis of rheumatoid arthritis by using germ?free animal models, and provide a theoreti?cal basis for further study of the role of intestinal microbiome in the pathogenesis of rheumatoid arthritis.
