Dynamical changes and significance of serum SOCS-3 in patients with acute pancreatitis
10.3760/cma.j.issn.1674-1935.2017.05.002
- VernacularTitle:急性胰腺炎患者血清SOCS-3水平的变化及其临床意义
- Author:
Zhenzhong ZHAO
1
;
Zhonghua XIE
;
Tiejun WANG
;
Yuanxiu ZHENG
;
Fangfang HUANG
Author Information
1. 杭州市余杭区第二人民医院内二科
- Keywords:
Pancreatitis;
SOCS-3;
Interleukin-6;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Pancreatology
2017;17(5):294-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamical changes of serum SOCS-3 in patients with acute pancreatitis (AP) and discuss the potential clinical significance.Methods Seventy-five patients with AP admitted in Yuhang District Second People's Hospital of Hangzhou City from February 2015 to December 2016 were selected,who were divided into 2 groups according to disease severity:40 cases in mild AP (MAP) group and 35 cases in moderate and severe AP (MSAP + SAP) group.The levels of serum SOCS-3,IL-6 and TNF-α were determined by enzyme linked immunosorbent assay (ELISA) on the 1,3,5 and 7 day after admission.Thirty healthy people who were age and gender matched were included in the normal control group.Results The levels of serum SOCS-3,IL-6 and TNF-α in AP patients on the 1 day after admission were significantly increased than that in the control group (P ＜ 0.01 or P ＜ 0.05),which were gradually increased with the time,peaked on the 5 day and then started to decrease on 7 day after admission which was still higher than that on the 1 day after admission.The levels of serum SOCS-3,IL-6 and TNF-α in MSAP + SAP group were significantly higher than that in MAP group (P ＜0.01),and there were significant differences (F =112.80,P =0.001;F =170.21,P =0.000;F =112.82,P =0.000).Significant differences were also found among different time points between two groups (F =258.38,P =0.000;F =4.82,P =0.000;F =5.52,P =0.001).Additionally,the significantly positive correlations of SOCS-3 with IL-6 and TNF-α were found (r=0.785,r=0.828,both P＜0.01).Conclusions SOCS-3 may participate in early excessive inflammatory reactions in AP.Dynamic detection of SOCS-3 may be helpful for AP clinical classification and prognosis evaluation.
