Research progress in late-onset hypogonadism
10.3760/cma.j.issn.0254-9026.2017.11.024
- VernacularTitle:中老年男性迟发型性腺功能减退症的研究进展
- Author:
Fengyi GAO
1
;
Guoping LI
Author Information
1. 100730,北京医院国家老年医学中心卫生部老年医学重点实验室
- Keywords:
Hypogonadism;
Testosterone
- From:
Chinese Journal of Geriatrics
2017;36(11):1267-1270
- CountryChina
- Language:Chinese
-
Abstract:
Late-onset hypogonadism(LOH)is an aging related syndrome with representative clinical manifestations.It has a serious impact on men's reproductive health and quality of life and is characterized by a deficiency in serum testosterone levels.Decline in Leydig cell number and function is the chief etiological factor.Changes in the biological activity of male hormones,androgen receptor abnormalities and hypothalamic-pituitary testicular axis feedback regulation dysfunction underliethe pathogenesis of LOH.Research directed at identifying safe and effective treatment methods for LOH will bring highly valuable development.
