Therapeutic effect analysis of Xingnaojing Injection combined with hyperbaric oxygen on patients with acute CO poisoning
10.3969/j.issn.1001-1528.2017.11.009
- VernacularTitle:醒脑静注射液联合高压氧对急性CO中毒患者治疗效果分析
- Author:
hai Ying TIAN
1
;
xia Qiu CHEN
;
ying Xiao DENG
;
bo Shu CHEN
;
ming Fang WU
;
Bin PI
;
juan Yu CHEN
Author Information
1. 广州医科大学附属第五医院急诊科
- Keywords:
Xingnaojing Injection;
acute carbon monoxide poisoning;
hyperbaric oxygen
- From:
Chinese Traditional Patent Medicine
2017;39(11):2269-2272
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the therapeutic effects of Xingnaojing Injection (Moschus,Gardeniae Fructus,Curcumae Radix,Borneolum Syntheticum) combined with hyperbaric oxygen on patients with acute carbon monoxide (CO) poisoning.METHODS Seventy-four cases of patients with acute CO poisoning treated from Jan 2013 to Jan 2016 in emergency department of our hospital were selected and randomly assigned into two groups.Control group was treated with hyperbaric oxygen,and observation group was treated with hyperbaric oxygen combined with Xingnaojing Injection.Clinical curative effects and the effects on levels of serum C-reactive protein (CRP),alanine aminotransferase (ALT),serum creatinine (Scr) between the two groups were compared.RESULTS Recovery time and hospitalization time in the observation group were significantly shorter,delayed encephalopathy rate was significantly lower,and efficacy rate was significantly higher than those in the control group,all the differences were statistically significant (P ＜ 0.05).After the treatment,serum MDA,CRP,ALT and Scr in the two groups were significantly decreased,and SOD was significantly increased as compared with those before the treatment.These indices in the observation group were significantly better than those in the control group,all the differences were statistically significant (P ＜ 0.05).CONCLUSION Xingnaojing Injection combined with hyperbaric oxygen can scavenge oxygen free radicals,inhibit inflammatory reaction,improve clinical symptoms,reduce delayed encephalopathy occurance,protect liver and kidney function and then improve clinical efficacy in the treatment of acute CO poisoning.
