Recent advances in cellular scaffolds for retinal pigment epithelium cell transplantation

VernacularTitle:视网膜色素上皮细胞移植支架技术研究进展
Author: Xinyi XIE ¹ ; Songtao YUAN ; Qinghuai LIU
Author Information

1. 210029,南京医科大学第一附属医院眼科
Keywords: Tissue scaffolds; Retinal pigment epithelium/transplantation; Macular degeneration/therapy; Review
From: Chinese Journal of Ocular Fundus Diseases 2017;33(6):655-658
CountryChina
Language:Chinese
Abstract: Replacement of diseased retinal pigment epithelium (RPE) cells with healthy RPE cells by transplantation is one option to treat several retinal degenerative diseases including age-related macular degeneration,which are caused by RPE loss and dysfunction.A cellular scaffold as a carrier for transplanted cells,may hold immense promise for facilitating cell migration and promoting the integration of RPE ceils into the host environment.Scaffolds can be prepared from a variety of natural and synthetic materials.Strategies,such as surface modification and structure adjustment,can improve the biomimetic properties of the scaffolds,optimize cell attachment and cellular function following transplantation and lay a foundation of clinical application in the future.