Intravesical injection of botulinum toxin A for treatment of interstitial cystitis/bladder pain syndrome: 13 years of experience
10.3760/cma.j.issn.1000-6702.2017.11.005
- VernacularTitle:A型肉毒毒素膀胱逼尿肌注射术治疗难治性间质性膀胱炎/膀胱疼痛综合征13年回顾分析
- Author:
Yi GAO
1
;
Limin LIAO
;
Lingna ZHAO
Author Information
1. 中国康复研究中心北京博爱医院泌尿外科 首都医科大学泌尿学系
- Keywords:
Interstitial cystitis/bladder pain syndrome;
Botulinum toxin-A;
Intravesical injection;
Hydrodistention;
Sodium hyaluronate
- From:
Chinese Journal of Urology
2017;38(11):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of the intravesical injection of botulinum toxin A (BTX-A) and bladder hydrodistention plus sodium hyaluronate (Cystistat) instillation in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).Methods We retrospectively reviewed 153 women with IC/BPS from January 2003 to December 2015.Of the 153 patients,77 were treated with BTX-A(group A),the average age was (56.0 ± 4.1) years old.76 underwent bladder hydrodistention plus sodium hyaluronate (Cystistat) instillation (group B),the average age was (58.0 ± 3.3) years old.The patients were evaluated using the O'Leafy-Saint score,visual analog scale pain score,urinary frequency record and quality of life questionnaire before treatment and 1 week,1,3,6 and 12 months after treatment.Results In group A,only 2 had acute urinary retention,27 received a repeat injection,and 28 were lost to follow-up.In group B,3 had urinary tract infection,15 switched to BTX-A injection at 6 months because the treatment of hydrodistention plus Cystistat instillation is not good.31 were lost to follow-up.BTX-A was shown to remain effective for up to 6 months after treatment.After repeated Chinese BTX-A injections,symptoms improved significantly.Hydrodistention plus Cystistat remained effective for up to 3 months after treatment.Conclusions Intravesical injection of BTX-A is a effective therapeutic option for patients with IC/BPS.The average duration of the effect of one dose of Chinese BTX-A was 6 months.Repeated injection of BTX-A is effective.
