An experimental model for rectourethral studies in the posterior urethra of the male canine
10.3760/cma.j.issn.1000-6702.2017.11.016
- VernacularTitle:尿道直肠瘘犬动物模型的建立
- Author:
Wensheng LI
1
;
Zhongling DOU
;
Guoqiang YU
;
Zhiyi ZHU
;
Zhaohui JIA
;
Hui LIU
Author Information
1. 河南科技大学临床医学院 河南科技大学第一附属医院泌尿外科
- Keywords:
Male mongrel dogs;
Urinary rectal fistula;
Animal model;
Urethral rrectum rradiography
- From:
Chinese Journal of Urology
2017;38(11):870-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective Objective To explore the best dog urethra rectum fistula operation method.Methods In June 2016 to October 2016,15 healthy male dogs were selected as research objects,aged 2-3 years (mean 2.5 years),with a body mass of 12-15 kg (mean 13.5 kg).They were randomly divided into three groups,each group of five.5 male dogs were cut through the rectum.5 male dogs were cut through the perineum.5 male dogs were cut through the rectal sphincter of the anus.Postoperative retrograde urethrectomy rectum angiography,the urethral pressure injection of methylene blue white gauze aizen rectum fistula and histologic evaluation of each group were compared 1,2,3 moths after the operation.Results Anal rectum drag cold knife cut group,1,2,3 moths after the operation,postoperative indicated the exist of orificium fistulae.The urethral pressure injection of methylene blue could observe rectum white gauze aizen,and pathological histology suggested the mucosal lamina propria disorder.There were a large number of inflammatory cells,5 dogs models were successfully built.Abdominal perineal pathway group:1 dog was killed by itself.1 dog one month after operation in anus at 2 cm below diameter about 3 cm appeared in a mixture of urine fistula and urethral orifice outflow,no urine outflow.More than 3 dogs after a week in the edge of serious infection,a canine model of severe dysuria,1,2,3 moths after the operation,postoperative indicated the exist of orificium fistulae.The urethral pressure injection of methylene blue could observe rectum white gauze aizen.3 dogs models were built.Through anal sphincter incision group:five dogs of the urethral fistula were successful,and one dog was incontinent with fecal incontinence.Conclusions The rectal rectum could successfully produce the animal model of the urethral rectal fistula and provide the experimental subjects for the treatment of iatrogenic urethral fistula.
