Effects of ligustrazine on blood rheology, aldose reductase and renal function in diabetic nephropathy rats
10.3969/j.issn.1001-1528.2017.11.002
- VernacularTitle:川芎嗪对糖尿病肾病大鼠血液流变学、醛糖还原酶及肾功能的影响
- Author:
Juan ZHONG
1
;
Wei QIN
;
Yao QING
;
rong Qing ZHONG
;
yue Shu WU
;
bo Lian WEI
Author Information
1. 南宁市第一人民医院
- Keywords:
ligustrazine;
diabetic nephropathy;
blood rheology;
aldose reductase;
renal function
- From:
Chinese Traditional Patent Medicine
2017;39(11):2231-2235
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the effects of ligustrazine on blood rheology,aldose reductase (AR) and renal function in diabetic nephropathy (DN) rats.METHODS The DN rat model was established by intraperitoneal injection of streptozotoein (55 mg/kg),rats were randomly divided into five groups,model group,irbesartan [50 mg/(kg · d)] group,high-,middle-and low-dose of ligustrazine [200,100,50 mg/(kg · d)] groups,together with normal control group.All the rats received daily garage for eight successive weeks.At the end of experiment,blood rheology,blood glucose,aldose reductase in erythrocyte and kidney tissue,24 h urinary protein,blood urea nitrogen,creatinine,creatinine clearance and renal function were observed.RESULTS Compared with the model group,blood rheology,blood glucose and renal function in various treatment groups were effectively improved,and aldose reductase activity was significantly decreased (P ＜ 0.05).HE staining and PAS staining showed that the pathological changes in kidney were significantly alleviated.CONCLUSION Ligustrazine can protect kidney of DN rats by ameliorating blood rheology,decreasing blood glucose and inhibiting aldose reductase activity.
