Preparation of colon-targeted pellets of Prunellae Spica effective components and the in vitro drug-release behaviors
10.3969/j.issn.1001-1528.2017.11.010
- VernacularTitle:夏枯草有效组分结肠靶向微丸的制备及其体外释药行为
- Author:
wei Jian ZHANG
1
;
Li LIU
;
Qin WANG
;
sheng De XU
Author Information
1. 上海中医药大学附属曙光医院
- Keywords:
Prunellae Spica;
effective components;
colon-targeted pellets;
in vitro drug-release behaviors;
fluidized bed coating method;
orthogonal test
- From:
Chinese Traditional Patent Medicine
2017;39(11):2273-2278
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare colon-targeted pellets of Prunellae Spica effective components and to evaluate the in vitro drug-release behaviors.METHODS Fluidized bed coating method was adopted in the preparation of pellets.With in vitro accumulative release rate as an evaluation index,hydroxypropyl methyl cellulose (HMPC),polyacrylic resin (Eudragit S100) and triethyl citrate (TEC) amounts as influencing factors,orthogonal test was applied to optimizing the formulation.The in vitro drug-release behaviors were evaluated with rosmarinic acid content as an index.RESULTS The optimal formulation was determined to be 5％ for HPMC amount,70％ for Eudragit S100 amount,and 20％ for TEC amount.The obtained pellets attained an accumulative release rate of more than 90％ in pH 7.6 PBS (transportation for 2 h),while no drug dissolution was found in pH 1.0 HCl (transportation for 2 h) or pH 6.8 PBS (transportation for 3 h).CONCLUSION Colon-targeted pellets of Prunellae Spica effective components can achieve in vitro colon-targeted effect.
