Urgent requirements for clinical translational studies in restoration of injured optic nerve
10.3760/cma.j.issn.1005-1015.2017.06.003
- VernacularTitle:亟待加强视神经损伤修复基础研究成果的临床转化
- Author:
Siwei YOU
1
;
Dan HU
;
Yusheng WANG
Author Information
1. 第四军医大学西京医院眼科全军眼科研究所
- Keywords:
Optic nerve injury;
Retinal ganglion cells;
Axons;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2017;33(6):569-572
- CountryChina
- Language:Chinese
-
Abstract:
The optic nerve belongs to the central nervous system (CNS).Because of the lack of neurotrophic factors in the microenvironment of the CNS and the presence of myelin and glial scar-related inhibitory molecules,and the inherent low renewal potentials of CNS neurons comparing to the peripheral nerve system,it is difficult to spontaneously regenerate the optic nerve after injury.Protecting damaged retinal ganglion cells (RGCs),supplementing neurotrophic factor,antagonizing axon regeneration inhibitory factor,and regulating the inherent regeneration potential of RGCs can effectively promote the regeneration and repair of optic nerve.Basic research has made important progress,including the restoration of visual function,but there are still a lot of unsolved problems in clinical translation of these achievements,so far there is no ideal method of treatment of optic nerve injury.Therefore,it is rather urgent to strengthen the cooperation between basic and clinical research,to promote the transformation of basic research to the clinical applications as soon as possible,which will change the unsatisfactory clinical application status.
