Analysis of PET and MRI in Alzheimer disease and mild cognitive impairment
10.13929/j.1003-3289.201708031
- VernacularTitle:阿尔茨海默病及轻度认知损伤患者PET与MRI分析
- Author:
Xiaoyi DUAN
1
;
Xiang LIU
;
Jiajun YE
;
Jungang GAO
;
Jie ZHENG
;
Youmin GUO
Author Information
1. 西安交通大学第一附属医院医学影像科PET-CT室
- Keywords:
Alzheimer disease;
Cognitive dysfunction;
Positron-emission tomography;
Magnetic resonance imaging;
Diagnostic imaging
- From:
Chinese Journal of Medical Imaging Technology
2017;33(11):1624-1629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the application value of PET glucose metabolic imaging and MR structural imaging in diagnosis of Alzheimer disease (AD) and mild cognitive impairment (MCI).Methods Totally 18 patients with AD (AD group),6 patients with MCI (MCI group) and 10 healthy volunteers (HC group) were enrolled.There were 11 cases of moderate or severe AD and 7 cases of mild AD in AD group.PET and structural MR imaging of the brain were performed.The radioactivity distribution in the brain and the hippocampal atrophy were observed through visually evaluation and quantitative analysis.Results The glucose metabolism reduced in certain regions of the brain in all AD patients (18/18,100％).Among them,11 patients with moderate or severe AD accompanied hippocampal atrophy,while 3 of 7 patients with mild AD showed hippocampal atrophy.No hippocampal atrophy was found in 5 patients with MCI (5/6,83.33 ％),but 2 of them showed decreased radioactivity in the brain.The symmetric mild diminution of radioactivity distribution without hippocampal atrophy was found in all subjects in HC group (10/10,100％).Two cases in HC group showed mild encephalanalosis.Conclusion Both of PET glucose metabolic imaging and MR structural imaging can be used to diagnose AD or MCI with different focus.Combination of these two techniques is helpful to improving diagnostic accuracy.
