Research progress of of long chain noncoding RNA in regulating osteogenic differentiation
10.16571/j.cnki.1008-8199.2017.11.019
- VernacularTitle:长链非编码RNA调节成骨分化的研究进展
- Author:
gang Xin PANG
1
;
rong Ni BAO
Author Information
1. 南京军区南京总医院骨科
- Keywords:
lncRNA;
Osteogenic differentiation;
Regulatory mechanisms
- From:
Journal of Medical Postgraduates
2017;30(11):1216-1221
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells are the main progenitor cells of osteoblasts , and are regarded as the seed cells for bone repair and regeneration because of their osteogenic differentiation potential .Promoting the osteogenic differentiation and bone formation is feasible to treat osteoporosis .LncRNAs regulate gene expression at the transcriptional and post-transcriptional levels , influence fundamental biological processes including cell differentiation and organ development , and are closely associated with many diseases including osteoporosis .This paper reviews the research of lncRNA in regulating osteogenic differentiation to provide a new tar -get for bone formation and treatment of osteoporosis .
