Analysis of Therapeutic Efficacy of Hyperthermia Combined with Pemetrexed and Cisplatin in the Treat-ment of Medium and Advanced Lung Adenocarcinoma
10.6039/j.issn.1001-0408.2017.33.14
- VernacularTitle:热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效分析
- Author:
Guobao ZHENG
1
;
Jianguo ZHANG
Author Information
1. 解放军第150中心医院肿瘤科
- Keywords:
Hyperthermia;
Pemetrexed;
Cisplatin;
Medium and advanced lung adenocarcinoma;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(33):4658-4660
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of hyperthermia combined with pemetrexed and cisplatin for medium and advanced lung adenocarcinoma. METHODS:Medical information of 120 patients with medium and advanced lung ade-nocarcinoma were analyzed retrospectively. They were divided into control group(60 cases)and observation group(60 cases)ac-cording to therapy method. Control group was given Pemetrexed disodium for injection 500 mg/m2 intravenously,d1+Cisplatin for injection 75 mg/m2 intravenously,d2-4. A treatment course lasted for 21 d,and both received 2 courses of treatment at least. Obser-vation group was additionally given hyperthermia,once a month,2-4 times in total,on the basis of control group. Clinical effica-cies,the improvement of life quality and the occurrence of toxic reaction were observed in 2 groups. RESULTS:Both groups re-ceived 2 courses of treatment at least. Total response rate of observation group(63.3%)was significantly higher than that of con-trol group(36.7%),and the improvement rate of life quality(60.0%)was significantly higher than control group(33.3%),with statistical significance (P<0.05). There was no statistical significance in Ⅲ-Ⅳ degree liver and renal function injury,myelosup-pression or the incidence of gastrointestinal tract between 2 groups (P>0.05). CONCLUSIONS: Hyperthermia combined with pemetrexed and cisplatin shows significant therapeutic efficacy for medium and advanced lung adenocarcinoma and improves surviv-al quality without increasing the occurrence of toxic reaction.
