Study on expression and clinical significance of NF-κBp65 protein and p62 protein in gastric carcinoma
10.3969/j.issn.1009-9905.2017.08.009
- VernacularTitle:NF-κBp65蛋白与p62蛋白在胃癌组织中的表达及意义
- Author:
Ling ZHANG
1
;
mei Hong ZHOU
;
shu Hong CHEN
;
hui Chun DOU
;
xin Cun ZHAO
;
dong Guo LIU
Author Information
1. 潍坊医学院临床医学院 山东潍坊261042
- Keywords:
Gastric carcinoma;
NF-κBp65;
p62
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(8):619-622
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive:To study the expression and clinical significance of NF-κ Bp65 protein and selective autophagy adaptor protein SQSTM1/p62 1(p62) in gastric carcinoma and its clinical significance.Methods:NF-κ Bp65 protein and p62 protein were determined in 72 cases of gastric carcinoma by immunohistochemistry PV-9000,and the relationship between them in the occurrence and development of gastric cancer was analyzed.Results:The positive expression of in gastric cancer tissues of NF-κ Bp65 (65.3％) was significantly higher than that of paracancerous gastric tissues (27.8％,P＜0.05);the positive expression rate of p62 (66.7％)was significantly higher than that in paracancerous gastric tissues (30.6％,P＜0.05);The expression of NF-κ Bp65,p62 was significantly correlated with the cancerous tissue differentiation degree,infiltrative depth,and lymph node metastasis (P＜0.05);NF-κ Bp65,p65 expression in the gastric cancer was positively correlated (P＜0.05).Conclusions:p62 and NF-κ Bp65 may be involved in apoptosis and cell proliferation of gastric carcinoma,and play anessential role in carcinogenesis.Detection of the two indexes would be used to assess and predict the prognosis of gastric cancer patients.
