Epidemiology and antifungal susceptibility analysis of Trichosporon asahii in urinary tract infection
10.13602/j.cnki.jcls.2017.10.12
- VernacularTitle:阿萨希毛孢子菌泌尿系感染的流行病学及药物敏感性分析
- Author:
yun Jun HUANG
1
;
xian Wen LU
;
qun Yi LIAO
;
dian Bao LING
;
fei Hong LU
Author Information
1. 赣南医学院第一附属医院检验科
- Keywords:
Trichosporon asahii;
urinary tract infection;
epidemiology;
isolation and identification;
drug susceptibility analysis
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(10):773-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the epidemiology,infection status,risk factors and microbiological characteristics of Trichosporon asahii in urinary tract infection for guidance of selecting the prompt and effective antifungal drugs in clinical therapy.Methods A total of 18 strains of Trichosporon asahii isolated from the patients with urinary tract infection were selected from 2013 to 2016.The isolation and identification of pathogenic bacteria,results of antimicrobial susceptibility test and clinical data were investigated by retrospective epidemiological survey.Results The 5 antifungal drugs,i.e.,5-fluorocytosine,amphotericin B,fluconazole,itraconazole and voriconazole,exhibited favorable antibacterial activity for the 18 strains of Trichosporon asahii with resistance rate of 0,5.6％,0,0 and 0 except itraconazole which showed only 50％ of sensitive rate.The risk factors of Trichosporon asahii infection in urinary system mainly included such as male,basic diseases (100％),long-term use of broad-spectrum antimicrobial agents (100％),indwelling catheter (83.3 ％),application of corticosteroids (50.0％) and immunosuppressive agents (38.9％) as well as a small proportion of granulocytopenia (5.6％).The 16 cases treated with fluconazole were improved,while the other 2 cases died following the treatment with itraconazole or voriconazole for reasons irrelevant to antifungal treatment.Conclusion Trichosporon asahii could cause urinary tract infections with high risk factors including basic diseases,long-term use of broad-spectrum antimicrobial agents,indwelling catheter,etc.The drug of top choice should be fluconazole.The key elements for successful treatment of Trichosporon asahii infection include early diagnosis of pathogens and correct selection of antifungal agents based on sensitivity and resistance tests of drugs.
