Interplay between hepatitis B virus and the type Ⅰ interferon system and new therapeutic strategies
10.3969/j.issn.1672-8467.2017.06.016
- VernacularTitle:乙型肝炎病毒与I型干扰素系统相互作用新机制及治疗新策略的研究
- Author:
liang Jie CHEN
1
;
hua Jian LI
;
nan Xiao ZHANG
;
Min WU
;
sheng Bi SHI
;
Zhong FANG
;
hong Zheng YUAN
Author Information
1. 复旦大学上海医学院教育部/卫计委医学分子病毒学重点实验室 上海 200032
- Keywords:
HBV;
IFN;
antiviral mechanisms;
viral antagonism and evasion;
novel therapeutic strategies
- From:
Fudan University Journal of Medical Sciences
2017;44(6):793-798
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection has been one of the most important public health problems,however,no complete cure is currently available.Although interferon (IFN)-α has been clinically used as a drug for chronic hepatitis B therapy because of its advantages including a higher rate of HBsAg/HBeAg seroconversion and a lower rate of recurrence after cessation of treatment,only 20％ -40 ％ of patients respond well to IFN therapy,thus hampering its clinical application.In recent years,based on the in vitro HBV replication and infection cell models,animal models and patient cohort with hepatitis B and by using a variety of methods,studies have been made.On the one hand,to identify new mechanisms underlying the IFN-and IFN-induced genes-mediated anti-HBV activities and signaling transduction,on the other hand,to reveal the effect and mechanisms of HBV replication and viral proteins in regulating the innate immune signaling pathways and IFN induction and antiviral action,based on which new strategies and approaches for optimization of IFN-based therapy and for a HBV cure have been further explored.This review mainly introduces the research findings of author's group and the future development is prospected.
