Role of RNF87 in predicting the prognosis of human hepatocellular carcinoma patients

VernacularTitle:E3泛素连接酶RNF87在肝细胞癌组织中的表达及意义
Author: kun Jian BI ^{1
,

2} ; 山东大学齐鲁医学部山东济南250012 ; ru Zhao DONG ; Dong SUN ; ze Hong SUN ; Chuang LIU ; gang Fa GUO ; Tao LI ; qiang Zhi CHEN ; Tao LI ; ting Xu ZHI
Author Information

1. 山东大学齐鲁医院普外科山东济南250012
2. 山东大学齐鲁医学部山东济南250012
Keywords: E3 ubiquitin ligase; RNF87; hepatocellular neoplasms; Gene expression
From: Chinese Journal of Current Advances in General Surgery 2017;20(8):623-626
CountryChina
Language:Chinese
Abstract: Objective:To investigate the level and prognostic significance of RNF87 in human hepatocellular carcinoma.Methods:Detected the expression of RNF87 in 98 HCC tissues by immunohistochemistry and Western Blot.According to the clinical data of the patients,we analyzed the relationship between RNF87 level and the prognosis of the HCC patients.Results:The level of RNF87 in HCC tissues is down-regulated,compared with the adjacent tissues.And the expression of RNF87 was significantly related to the prognosis of HCC patients.Besides,the lower level of RNF87 was also obviously related with microvascular invasion.Conclusions:The down-regulated level of RNF87 may be one of the risk factors of human hepatocellular carcinoma progression;RNF87 maybe one of potential tumor suppressors;the level of RNF87 can be used as an indicator to predict the prognosis of HCC patients.