Expression and significance of PTEN/PI3K/AKT/mTOR signaling pathway in extranodal NK/T cell lymphoma
10.3969/j.issn.1671-8348.2017.32.014
- VernacularTitle:PTEN/PI3K/AKT/mTOR信号通路在结外NK/T细胞淋巴瘤中的表达及临床意义
- Author:
Tao MA
1
;
Hongyun XING
;
Tierong BIAN
;
Xiaoming LI
;
Yan CHEN
;
Juan HUANG
Author Information
1. 西南医科大学附属医院血液内科
- Keywords:
lymphoma,extranodal NK-T-cell;
nasal type;
mTOR signaling pathway;
pathogenesis;
prognosis
- From:
Chongqing Medicine
2017;46(32):4514-4516,4519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investgate the pathogenesis of PTEN/PI3K/AKT/mTOR signaling pathways in nasal type extranodal NK/T cell lymphoma(ENKTCL-N).Methods The expression of PTEN,p-AKT,p-4EBP1 and p-mTOR in 51 patients with ENKTCL-N and 20 patients with reactive proliferative lymph nodes was detected by immunohistochemistry EnVision.The clinical data were collected and the clinical features,curative effect and prognosis were analyzed retrospectively.Survival analysis was performed by Kaplan-Meier method.Results The positive rate of PTEN in ENKTCL-N patients was lower than that in patients with reactive hyperplastic lymph nodes,and the positive rates of p-AKT and p-4EBP1 were higher than those in patients with reactive hyperplastic lymph nodes,and the difference was statistically significant(P＜0.05);The positive rate of p-mTOR in ENKTCL-N patients was higher than that in patients with reactive hyperplastic lymph nodes,but the difference was not statistically significant (P＞0.05).The survival rate of PTEN-positive patients was higher than that of PTEN-negative patients,and the difference was statistically significant(P＜0.05).Conclusion PTEN/PI3K/AKT/mTOR signaling pathway is abnormally active in ENKTCL-N,which may be related to its pathogenesis;PTEN-positive patients may have better prognosis.
