Clinical observation on Tongluoyuzufang Ⅰ for patients with diabetic foot
10.3969/j.issn.1671-8348.2017.32.007
- VernacularTitle:通络愈足工号方治疗糖尿病足患者的临床疗效观察
- Author:
Xiangxiu LIU
1
;
Anyu WANG
;
Bo LI
;
Xi CHEN
Author Information
1. 贵阳中医学院第一附属医院内分泌科
- Keywords:
Tongluoyuzufang Ⅰ;
diabetic foot;
tumor necrosis factor-α;
vascular endothelial growth factor;
anti-thrombin-Ⅲ
- From:
Chongqing Medicine
2017;46(32):4488-4491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and its mechanism of Tongluoyuzufang Ⅰ in patients with diabetic foot (DF).Methods A total of 60 cases with DF was randomly divided into experimental group and control group,30 cases in each group.All patients were given insulin and/or hypoglycemic drugs and other Western medicine comprehensive treatment to control blood sugar steadily.The control group received methylcobalamin treatment,and the experimental group received Tongluoyuzufang Ⅰ therapy treatment based on the methylcobalamin treatment.Both groups were treated for 4 weeks for a course of treatment.The clinical efficacy,ankle-brachial index,nerve conduction velocity,hemorheology,blood lipid,serum cytokines and adverse reactions before and after treatment were compared after 3 courses of treatment.Results After treatment,the total effective rate was 90.0 ％ in the observation group,higher than that in the control group(x2 =5.963,P＜0.05).After treatment,the ankle-brachial index,nerve conduction velocity,hemorheology and blood lipid level in both groups were significantly improved(P＜0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor(VEGF) in both groups were significantly decreased,while the levels of anti-thrombin Ⅲ (AT-Ⅲ) has increased(P＜0.05).The improvement of the indexes in the observation group was better than that in the control group(P＜0.05).There were no serious adverse events during treatment.Conclusion Tongluoyuzufang Ⅰ can significantly improve limb ischemia and nerve conduction function in patient with DF.
