Application and advantages of tissue engineering technique in the treatment of infected bone defects
10.3969/j.issn.2095-4344.2017.28.019
- VernacularTitle:组织工程技术在感染性骨缺损治疗中的应用及优势
- Author:
xiang Bu WANG
1
;
yi Tie YANG
;
qun Zhen ZHAO
;
bing Shi GUO
Author Information
1. 内蒙古医科大学研究生学院
- From:
Chinese Journal of Tissue Engineering Research
2017;21(28):4543-4549
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:There are many treatment methods for infected bone defects,but there is no first stage treatment method,which has the characteristics of sustained-release,anti-inflammation,osteogenic activity,bone conduction and degradable absorption.OBJECTIVE:To investigate the research progress of bone tissue engineering technique in the treatment of infected bone defects.METHODS:A computer-based retrieval of PubMed,WanFang and CNKI databases was conducted for the articles published from 2000 to 2016,concerning the basic and clinical research on the local application of antibiotics;basic research on infected bone defects with sustained-release of antibiotics;basic studies on the source of seed cells and the osteogenic mechanism;and scaffold materials.A total of 55 eligible articles were included for result analysis.RESULTS AND CONCLUSION:Topical application of antibiotics exhibits different effects in the treatment of osteomyelitis.The development of bone tissue engineering has brought new hope for the treatment of bone defects,and in the meanwhile,selection of excellent seed cells has become a hot and difficult research.A rational combination of antibiotics,seed cells and scaffold materials may provide a new treatment strategy for infected bone defects.
