Relationship between M2 microphage infiltration and the malignant degree of prostate cancer

VernacularTitle:M2型巨噬细胞浸润与前列腺癌恶性程度的相关性分析
Author: qing Guo WANG ¹ ; Tao TAO ; Huan SU ; qing Xue WANG ; qiu Shu CHEN ; Ming CHEN ; hua Li ZHANG
Author Information

1. 东南大学附属中大医院病理科
Keywords: prostate neoplasm; macrophage; pathological grading; clinical stage
From: Chinese Journal of Clinical and Experimental Pathology 2017;33(9):969-971
CountryChina
Language:Chinese
Abstract: Purpose To investigate the relationship between M2 microphage infiltration and the pathological grading and staging of prostate cancer.Methods 58 patients who accepted the radical resection of prostate cancer were selected.After operation,pathologic specimens were hematoxylin eosin stained and immunohistochemical of SP stained to identify the pathological grading,staging,and M2 microphage infiltration.Then,Chi-squared test was used to analyze the relationship between M2 microphage infiltration and the pathological grading and staging of prostate cancer.Results There were 71.4％ high stage (≥T2c) cases and 60％ lymph node metastasis cases in M2 microphage infiltration group,which was significantly higher than those in non M2 microphage infiltration group.However,there was no relationship between M2 microphage infiltration and pathological grading.Conclusion M2 macrophage infiltration may participate in the prostate cancer cell growth and metastasis,whose pathophysiological mechanism needs further exploration.