Analysis of c-MET, ALK, ROS1 variants in non-small cell lung cancer and its clinical significance
10.13315/j.cnki.cjcep.2017.09.012
- VernacularTitle:晚期非小细胞肺癌中c-MET、ALK、ROS1基因突变的相关性及临床意义
- Author:
dong Wei ZHU
1
;
xi Chen SHI
;
en San LI
;
chuan Ling GUO
Author Information
1. 苏州大学附属第一医院病理科
- Keywords:
lung neoplasm;
non-small cell lung cancer;
c-MET gene amplification;
clinicopathologic features;
ALK fusions;
ROS1 fusions
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(9):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The aim was to examine c-MET,ALK,ROS1 variants in advanced non-small cell lung cancer (NSCLC) patients,and to analysis the association of c-MET,ALK,ROS1 variants with the clinical and pathological features.Methods The c-MET,ALK,ROS1 were detected by fluorescence in situ hybridization (FISH) in the 91 cases of NSCLC specimens.The correlation of c-MET gene amplification with clinicopathological features and the ALK,ROS1 fusions was analyzed.Results The positive rate of c-MET gene amplification was 8.79％ (8/91),the positive rates on male and female were 1.82％ and 19.4％,respectively.In ＜ 60-years-old and ≥60-years-old NSCLC patients,the positive rates were 7.5％ and 8.89％,resepectively.The positive rate was higher in stage Ⅲ than stage Ⅳ (9.62％ vs 7.69％),the c-MET gene amplification was detected in 9.2％ adenocarcinoma patients but none in squamous carcinoma patients.The detection rates of ALK fusions and ROS1 fusions were 10％ and 13.3％,respectively.One patient was detected the coexistence of MET with ROS1 fusion.Conclusion The c-MET gene amplification is correlated with gender,but not with age,histological types and clinical stages.C-MET amplification,ALK fusions and ROS1 fusions are almost no coexistence,but not completely mutually exclusive.To they knowledge,this is the first case report the coexistence of MET amplification with ROS1 fusion in NSCLC.
