Clinical characteristics and microbiological spectrum of 144 cases of infective endocarditis
10.16718/j.1009-7708.2017.05.003
- VernacularTitle:144例感染性心内膜炎临床及病原学特点分析
- Author:
Xuzhu MA
1
;
Xiangyan LI
;
Bo ZHENG
Author Information
1. 清华大学附属北京清华长庚医院普通内科
- Keywords:
infective endocarditis;
congenital heart disease;
degenerative valvular disease;
Streptococcus viridans
- From:
Chinese Journal of Infection and Chemotherapy
2017;17(5):498-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and microbiological pathogens associated with infective endocarditis (IE) in Chinese patients in a university hospital over a 10-year period.Methods We retrospectively evaluated 144 adult IE patients admitted to Peking University First Hospital from 2006 to 2015.Statistical analysis was performed to analyze data on demographics,clinical and laboratory findings,as well as microbiological pathogens.Results The mean age of the 144 patients was 46.6 years.The male to female ratio was 2.3.The most common underlying heart diseases were congenital heart disease (22.9％),followed by degenerative valvular disease (18.8％) and rheumatic heart disease (10.4％).The most common clinical manifestation was fever (91.7％),followed by cardiac murmur (90.3％) and anemia (76.4％).Mitral (40.3％) and aortic valves (39.6％) were most frequently affected.The right-sided IE cases were all found in patients with congenital heart disease.Positive blood culture was documented in 87 IE patients.Streptococcus viridans was the most common pathogen (55.2％,48 episodes),followed by Staphylococcus (24.1％,21 episodes).The prevalence of methicillin-resistant Staphylococcus was 38.1％.Forty-eight (94.1％) of the 51 strains of Streptococcus spp.were susceptible to penicillin.Conclusions Congenital heart disease and degenerative valvular disease have overtaken rheumatic heart disease as the major underlying heart diseases associated with IE.Streptococcus viridans is still the most common pathogen ofIE in China.
