Ghrelineffects on the growth hormone release, osteoblast proliferation and bone growth
10.3969/j.issn.2095-4344.2017.32.021
- VernacularTitle:Ghrelin对生长激素释放、成骨细胞增殖及骨生长的效应
- Author:
feng Yu CHEN
1
;
lin Hui YANG
;
Jun ZOU
Author Information
1. 苏州大学附属第一医院骨科
- From:
Chinese Journal of Tissue Engineering Research
2017;21(32):5209-5214
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: The balance between bone formation and bone resorption plays an important role in maintaining bone mass, and the stability and balance of the internal environment are affected by many factors.Ghrelin, a major hormone that regulates the secretion of growth hormone, plays a critical part in bone remodeling and body energy metabolism.OBJECTIVE: To investigate the effect of ghrelin on the release of growth hormone and its effect on osteoblast proliferation and bone growth.METHODS: PubMed and WanFang databases were retrieved for the Chinese and English literature addressing the mechanism of ghrelin and the effects of ghrelin on osteoblast proliferation, bone metabolism and bone remodeling published from 1999 to 2016. The repetitive articles were excluded.RESULTS AND CONCLUSION: Ghrelin is involved in the regulation of pituitary growth hormone release, energy metabolism, inflammatory response and osteogenesis. Ghrelin can promote the differentiation and proliferation of osteoblasts and can be secreted by chondrocytes, participating in bone metabolism and growth. Ghrelin can be used as an important target of bone growth, but its mechanism is complex and needs to be further studied.
