Expression change of PTGFR gene in articular capsule and ligamentum teres in DDH and its correlation with pathogenesis of DDH

VernacularTitle:PTGFR基因在DDH患儿关节囊和圆韧带中的表达变化及其与DDH发病的相关性研究
Author: Lihua ZHAO ¹ ; Qing JIAO ; Mengjie CHEN ; Yichen WANG ; Lingyan FAN ; Feng MA ; Hao YING ; Sun WANG
Author Information

1. 上海市儿童医院/上海交通大学附属儿童医院骨科 200062
Keywords: joint capsule; round ligament; developmental dysplasia of the hip; prostaglandin F2αreceptor gene
From: Chongqing Medicine 2017;46(33):4613-4615
CountryChina
Language:Chinese
Abstract: Objective To analyze the expression change of PTGFR gene in hip joint tissues of development dysplasia of the hip (DDH) and its correlation with DDH pathogenesis .Methods Eight age-and gender-matched children with DDH (DDH group) and control children (control group) were enrolled for conducting the compaison .The real-time quantitative PCR method and West-ern-blot method were adopted to detect the PTGFR mRNA and protein expression levels .Results PTGFR mRNA expression level in the hip articular capsule and ligamentum teres of the DDH group were significantly decreased compared with those of the control group (t=3 .472 ,2 .887 ,P<0 .05 ,) .The PTGFR protein expression level in the hip articular capsule and ligamentum teres of the DDH group were significantly decreased compared with those of the control group (t=5 .488 ,3 .942 ,P<0 .05) .Conclusion PTG-FR could play an important role in DDH pathogenesis and may be one of DDH pathogenic genes .