Effect of modified gastric bypass on glycometabolism of non-obese type 2 diabetes mellitus in GK rats
10.3969/j.issn.1671-8348.2017.33.003
- VernacularTitle:改良的胃旁路术对GK大鼠非肥胖2型糖尿病的糖代谢影响研究
- Author:
Guanghua PEI
1
;
Haitao HU
;
Yuwen LIN
;
Jin ZHUGE
;
Jin ZHAO
Author Information
1. 广东药学院附属第二医院/广州新海医院普外科 510300
- Keywords:
modified gastric bypass;
Roux-en-Y gastric bypass;
non-obese type 2 diabetes mellitus;
GK rat
- From:
Chongqing Medicine
2017;46(33):4616-4618,4621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the feasibility and effectiveness of modified gastric bypass surgery in the treatment of non-obese type 2 diabetic mellitus(T2DM ) GK rats .Methods Forty male GK rats were randomly divided into four groups (n=10) ,the group A served as the modified gastric bypass ,group B as the Roux-en-Y gastric bypass ,group C as the sham operation and group D as the blank control group .Fasting blood glucose(FBG) ,glycosylated hemoglobin(HbA1c) and fasting serum insulin(FINS) in each group were detected at preoperative 1 week ,postoperative 1 ,2 ,4 ,8 ,12 weeks .Results The rat body mass at postoperative 1 week in the group A and B was significantly decreased compared with the group D ,and began to recover at postoperative 4 weeks , the rat body mass at the same time point had no statistical difference between the group A and B (P>0 .05) .FPG ,FINS and HbA1c at preoperative 1 week had no statistical difference among various groups (P>0 .05) .FPG and FINS at postoperative 1 week had no statistical difference among various groups (P>0 .05) .FPG and FINS at postoperative 2 ,4 ,8 ,12 weeks had no statistical difference between the group A and B(P>0 .05) ,which had no statistical difference between the group A with the group C and D (P>0 .05) . HbA1c at postoperative 4 weeks had no statistical difference among various groups (P>0 .05);which at postoperative 12 weeks had no statistical difference between the group A and B (P>0 .05) ,while which had no statistical difference between the group A with the group C and D(P>0 .05) .Conclusion The modified gastric bypass surgery has the improvement effect on glycometabolism of rat non-obese T2DM ,which is similar to that of Roux-en-Y gastric bypass surgery .
