Risk factors of hemorrhagic transformation in 335 patients with acute cerebral infarction
10.3969/j.issn.1671-8348.2017.32.022
- VernacularTitle:335例急性脑梗死患者出血转化的危险因素探讨
- Author:
Huiqin BI
1
;
Lili CHEN
;
Li YUAN
;
Jiang LIU
;
Sujie WANG
;
Jianxing ZHANG
;
Guojuan CHEN
;
Jingjing LI
;
Pei LI
;
Haiying WANG
Author Information
1. 河北省唐山市工人医院神经内科 063000
- Keywords:
brain infarction;
hemorrhagic transformation;
atrial fibrillation;
fasting blood glucose;
large area infarction;
thrombolytic therapy
- From:
Chongqing Medicine
2017;46(32):4540-4543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of hemorrhagic transformation(HT) in patients with acute cerebral infarction(ACI).Methods A total of 335 patients with ACI from June 2013 to September 2016 was enrolled in this study,including 47 patients in hemorrhagic transform group(HT group) and 288 patients in non-hemorrhagic transformation group(NHT group).The general clinical situation,laboratory indexes,imaging features and treatment measures of the two groups were collected and compared,and then the risk factors of HT in the patients with ACI were analyzed by Logistic regression analysis.Results Univariate analysisshowed that there were significant differences between the two groups in the history of diabetes mellitus,hìstory of atrial fibrillation,NHISS score,systolic blood pressure at admission,fasting blood glucose,glycosylated hemoglobin,low density lipoprotein cholesterol,fibrinogen,infarct location,large area infarction and thrombolytic therapy(P＜0.05).Logistic regression analysis showed that history of atrial fibrillation(OR =2.703,95 ％ CI 1.169-6.250),high fasting blood glucose(OR =2.098,95 ％ CI 1.532-2.875),large area infarction(OR=9.999,95％CI 4.648-21.510) and thrombolytic therapy(OR=6.557,95％CI 1.954-22.003) were independent risk factors for HT.Conclusion The history of atrial fibrillation,high fasting blood glucose,large area infarction and thrombolytic therapy are the risk factors for HT in patients with ACI.Corresponding nursing measures should be arranged to facilitate the disease treatment.
