Abnormal gray matter volume and regional homogeneity of resting fMRI in patients with schizophrenia and obsessive-compulsive disorder
10.3969/j.issn.1000-6729.2017.10.004
- VernacularTitle:精神分裂症和强迫障碍患者的全脑灰质体积及静息态脑功能局部一致性
- Author:
Xi Xiao ZHANG
1
;
Jing LI
;
Min Jin LIAO
;
Si Si JIANG
;
Jun YAN
;
Hao YAN
;
Dai ZHANG
Author Information
1. 北京大学第六医院
- Keywords:
schizophrenia;
obsessive compulsive disorder;
voxel-based morphometry;
grey matter volume;
regional homogeneity
- From:
Chinese Mental Health Journal
2017;31(10):768-774
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the traits of gray matter volume (GMV) and regional homogeneity (ReHo) in patients with schizophrenia and obsessive-compulsive disorder (OCD) by magnetic resonance imaging technique (MRI).Methods:Twenty-two patients with schizophrenia,20 patients with OCD and 23 normal controls were recruited in this study.All of the patients satisfied diagnostic criteria from the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition (DSM-Ⅳ),patients and the normal controls were well matched for gender,age and years of education.All subjects received structural magnetic resonance imaging (MRI) scans and resting functional MRI scans.The ANOVA and post hoe anolysis were used to compoare the GMV and Relto differences among the subjects.Results:Compared with the normal controls,patients with schizophrenia and OCD had common GMV loss in the right anterior cingulate (P ＜ 0.001,uncorrected),while lower ReHo in the left cuneus(P ＜ 0.001,uncorrected) and higher ReHo in the left upper medial frontal gyrus(P ＜ 0.001,uncorrected) respectively.Conclusion:It suggests that patients with schizophrenia and OCD share common structural changes and functional alterations,which could attribute so many similarities between the two diseases.
