Mechanism of Dan Hong Treatment of Cervical Spondylotic Myelopathy

VernacularTitle:丹红提取物对脊髓型颈椎病的治疗机制初探
Author: Jiaxiang YANG ¹ ; Huanwei YANG ; Junge DONG ; Jian YU ; Yanan HU ; Jun LIANG ; Yange TANG
Author Information

1. 河北省中医院骨伤一科
Keywords: Dan Hong; cervical spondylotic myelopathy; inflammation; apoptosis
From: Journal of China Medical University 2017;46(8):710-712,719
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic mechanism of Dan Hong in a rat model of cervical spondylotic myelopathy (CSM).Methods Thirty Sprague-Dawley rats were divided into an experimental group (n=10),aCSM modelgroup (n=10),and acontrol group (n=10).The CSM model group received a Dan Hong injection,while the control and experimental groups received an injection of an equivalent volume of physiological saline.The motor function of the rats was assessed before administration and at 4 weeks after administration,at which time the rats were sacrificed.The expression of cytokines and bcl-2 was detected by ELISA and Westem blotting.Results Four weeks after treatment,the number of oblique plates in the experimental group increased.Additionally,the expression of cytokines (IL-6 and TNF-α) in the CSM model group was higher and the expression of bcl-2 was lower.Conclusion Dan Hong injection can reduce the inflammatory response and reduce cell apoptosis in CSM.