Investigation of the Relationship between Cognitive Function and MRI Manifestation in Patients with SHPT
10.12007/j.issn.0258-4646.2017.08.011
- VernacularTitle:肾性继发性甲状旁腺功能亢进症患者大脑影像学表现与认知功能的相关性研究
- Author:
Rong JI
1
;
Li HAO
;
Sen ZHANG
;
Suisheng ZHENG
;
Yanqi SHAN
Author Information
1. 安徽医科大学第二附属医院肾内科
- Keywords:
chronic renal failure;
hyperparathyroidism;
magnetic resonance imaging;
diffusion weighted imaging;
diffusion tensor imaging;
cognition
- From:
Journal of China Medical University
2017;46(8):720-723,728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cognitive function and magnetic resonance imaging (MRI) manifestations in patients with secondary hyperparathyroidism (SHPT) by analyzing brain MRI diffusion-weighted imaging,diffusion tensor imaging,serological markers,and cognitive function.Methods We evaluated 49 random patients with SHPT.We adopted two functional scales to evaluate cognitive function and performed MRI fractional anisotropy (FA) and apparent diffusion coefficient (ADC) to evaluate white matter function of brain functional areas.We recorded serological markers,and conducted statistical analysis to analyze correlation among cognitive function scores,brain MRI in white matter functional areas,and biochemical parameters.Results We found that at the frontal area,the FA and ADC values were correlated with the MMSE language and memory function scores;at the parietal area,the FA and ADC values were correlated to the MoCA visuospatial executive function scores;the other areas had no significant correlation with cognitive function scale score.Cognitive function was negatively correlated with immunoreactive parathyroid hormone (iPTH) levels but positively correlated with education level,while it was not correlated with sex,age,blood pressure,and serum calcium levels in patients with SHPT.Conclusion In patients with SHPT,cognitive function is correlated with iPTH level and education level.The FA and ADC values of brain MRI in the frontal and parietal lobes might play a diagnostic role in evaluating cognitive function and locating injury for patients with SHPT,which requires clinical attention.
