The Expression and Significance of miR-608 in Ameloblastoma
10.12007/j.issn.0258-4646.2017.08.012
- VernacularTitle:miR-608在成釉细胞瘤中的表达及意义
- Author:
Jingyang CHEN
1
;
Ming ZHONG
;
Wenjing SHEN
;
Jie LIU
Author Information
1. 中国医科大学基础医学院生物化学与分子生物学教研室
- Keywords:
ameloblastoma;
miR-608;
quantitative stem-loop RT-PCR;
tumor recurrence
- From:
Journal of China Medical University
2017;46(8):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of miR-608 in ameloblastoma (AB).Methods Quantitative stem-loop RT-PCR was used to detect the expression of miR-608 in 26 cases of human AB (AB group) and 17 cases of peritumoural tissues (control group).The differences in miR-608 levels between the control group and the AB groups,namely,primary AB and recurrent AB,were evaluated.In addition,miR-608 levels in AB cases with different clinical and pathological characteristics were compared.Results The expression level of miR-608 in the AB group was significantly lower than that in the control group (P < 0.05).Additionally,the relative expression level of miR-608 in the primary AB group was significantly lower than that in the recurrent AB group (P < 0.05).There were no significant differences between the miR-608 expression levels with respet to age,gender,or pathological type (P > 0.05).Conclusions The expression of miR-608 in human AB tissue is significantly decreased,which may be related to the recurrence of the tumor.