Research progress on relationship between complement activation and tumor immunity
10.3760/cma.j.issn.1009-9158.2017.09.006
- VernacularTitle:补体活化与肿瘤免疫关系的新进展
- Author:
Lingling ZHANG
1
;
Weiran XU
;
Jun LIANG
Author Information
1. 102206,北京大学国际医院肿瘤内科
- Keywords:
Complemeut activation;
Tumor escape;
Monitoring,immunologic
- From:
Chinese Journal of Laboratory Medicine
2017;40(9):664-666
- CountryChina
- Language:Chinese
-
Abstract:
Complement system is a central part of the innate immune response that has developed as a first defense against non-self cells.Complement activation has traditionally been considered part of the body's immunosurveillance against cancer.However,recent studies have demonstrated that activated components of the complement system can assist the escape of tumor cells from immunosurveillance,promote angiogenesis,activate mitogenic signaling pathways,sustain cellular proliferation and insensitivity to apoptosis,and participate in tumor cell invasion and migration.This review reviewed the progress of complement activation and tumor immune surveillance and immune evasion,in order to provide a new strategy for antitumor immunotherapy.
