Literature Analysis of 118 Cases of Propylthiouracil-associated Small Vasculitis

VernacularTitle:丙基硫氧嘧啶致相关性小血管炎118例文献分析
Author: Xiaojiang TIAN ¹ ; Xuewen TANG ; Huanhuan JI ; Yuntao JIA
Author Information

1. 重庆医科大学药学院
Keywords: Propylthiouracil; Associated small vasculitis; ADR; Literature analysis
From: China Pharmacy 2017;28(33):4644-4647
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate the general regularity and characteristics of propylthiouracil (PTU)-associated small vasculitis (ASV),and to provide reference for rational drug use in the clinic. METHODS:ADR/ADE case reports of PTU-ASV published during 1990-2016 were retrieved. The data of 118 ADR cases were analyzed statistically. RESULTS:The incidence of PTU-ASV was higher in female and was highest in 18-59 age group. Drug dose of 87 patients were within 600 mg/d,and the inci-dence of PTU-ASV was the highest within 1-5 years after medication. Main clinical manifestations were renal and lung function in-jury. After drug withdrawal,59 patients received hormone therapy,and 30 patients received hormone combined immunosuppressive agent. Finally,115 patients were recovered and 3 patients died. CONCLUSIONS:In older to reduce or avoid the occurrence of ADR,it is necessary to regularly check antineutrophil cytoplasmic antibody related indexes and evaluate the symptoms of ADR.