Meta-analysis of the Effects of Multi-drug Resistance Gene MDR1 C3435T Gene Polymorphism on Thera-peutic Efficacy of Proton Pump Inhibitors-based Triple Therapy for Helicobacter pylori Eradication
10.6039/j.issn.1001-0408.2017.33.18
- VernacularTitle:多药耐药基因MDR1 C3435T基因多态性对质子泵抑制剂三联方案根除幽门螺杆菌疗效影响的Meta分析
- Author:
Qianghong PU
1
;
Qiuju LYU
Author Information
1. 乐山市人民医院
- Keywords:
Multi-drug resistance gene;
MDR1 C3435T gene;
Gene polymorphism;
Proton pump inhibitor;
Helicobacter pylo-ri;
Meta-analysis;
Therapeutic efficacy
- From:
China Pharmacy
2017;28(33):4671-4675
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the relationship of multi-drug resistance gene MDR1 C3435T gene polymor-phism with therapeutic efficacy of proton pump inhibitors (PPIs)-based triple therapy for Helicobacter pylori eradication. METH-ODS:Retrieved from PubMed,EMBbase,CBM,CJFD,Wanfang database and VIP,clinical studies about MDR1 C3435T gene polymorphism and PPIs-based triple therapy for the eradication of H. pylori infection were collected. Meta-analysis was performed by using Rev Man 5.3 statistical software after data extraction and quality evaluation by using STREGA statement. RESULTS:A to-tal of 7 studies were included,involving 1019 patients. The results of MDR1 C3435T genotyping in patients were classified as wild homozygote genotype(CC),mutant heterozygous genotype(CT)and mutant homozygote genotype(TT). The results of Me-ta-analysis showed that there was no statistical significance in the eradication rate of H. pylori among CC,CT and TT groups of MDR1 C3435T gene polymorphism [CC vs. CT:OR=0.99,95%CI(0.69,1.42) ,P=0.95;CC vs.TT:OR=1.44,95%CI(0.66, 3.15),P=0.36;CT vs.TT:OR=1.54,95%CI(0.86,2.73),P=0.14]. Subgroup analysis showed the eradication rate of H. pylori in CT genotype group was higher than that in TT genotype group among Asian population [OR=2.35,95%CI(1.53,3.62),P<0.001]. CONCLUSIONS:MDR1 C3435T gene polymorphism basically do not affect therapeutic efficacy of PPIs-based triple thera-py for H. pylori eradication. For Asian population,gene detection is useful for the treatment.
