Advances in Research on the Mechanism of Calcium/calmodulin-dependent Protein Kinase Ⅱ in Epilepsy
10.12007/j.issn.0258-4646.2017.07.001
- VernacularTitle:钙离子/钙调蛋白激酶Ⅱ在癫痫中的作用机制
- Author:
Shuoyan XU
1
;
Qianhui WANG
;
Feng GUO
Author Information
1. 中国医科大学
- Keywords:
calcium/calmodulin-dependent protein kinase Ⅱ;
epilepsy;
cellular specificity;
colocation effect;
synaptic plasticity
- From:
Journal of China Medical University
2017;46(7):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Calcium/cahnodulin-dependent protein kinase Ⅱ (CaMK Ⅱ) is a multifunctional serine/threonine protein kinase.It plays a vital role in the regulation of neurotransmitters,cell metabolism,and synaptic plasticity,as well as in many diseases of the nervous system.As CaMK Ⅱ alpha is specifically located at excitatory neurons,it has long been regarded as crucial for the treatment of epilepsy.CaMK Ⅱ shows decreased activity after seizures in different in vivo and in vitro models of epilepsy.This article provides a new theoretical basis for further research on the pathological process of epilepsy and its treatment,by exploring several recent experimental studies on CaMK Ⅱ and epilepsy.
