Expression and Clinical Significance of Periostin in Breast Cancer
10.12007/j.issn.0258-4646.2017.07.012
- VernacularTitle:骨膜蛋白在乳腺癌中的表达及临床意义
- Author:
Yu CAO
1
;
Wenliang DONG
;
Liang LIU
;
Xiangjun CAI
Author Information
1. 中国人民解放军第202医院普外科
- Keywords:
breast cancer;
immunohistochemistry;
periostin
- From:
Journal of China Medical University
2017;46(7):628-631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of periostin (PN) in breast cancer and its adjacent tissues.Methods We evaluated 50 women with breast cancer.We determined PN expression by immunohistochemistry and analyzed positive expression in the tumors and adjacent tissue by paticnt age,TNM stage,SBR type,pathological type,lymph node metastasis,and other factors.Results PN expression in breast cancer and cancer adjacent tissues was associated with an increase in TNM staging (P =0.024),SBR type (P =0.012),and lymphatic metastasis (P =0.035).However,there was no significant correlation between age or pathological type (P ＞ 0.05).Condusion Expression of PN in breast cancer is associated with TNM staging,SBR type,and lymph node metastasis,and is involved in the pathological progression of breast cancer.PN may be a potential prognostic marker for breast cancer.
