Expression and Clinical Significance of CXCR1 and CXCR2 in Triple-negative Breast Cancer
10.12007/j.issn.0258-4646.2017.07.014
- VernacularTitle:三阴乳腺癌中CXCR1和CXCR2的表达及临床意义
- Author:
Xiaoting ZHAO
1
;
Jie SUN
;
Shuang LIU
;
Yang BAI
;
Xing WANG
;
Rui CHU
;
Cuifang WANG
Author Information
1. 沈阳医学院基础医学院研究生院
- Keywords:
CXCR1;
CXCR2;
triple-negative breast cancer;
immunohistochemistry
- From:
Journal of China Medical University
2017;46(7):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2) in triplenegative breast cancer (TNBC) and its significance.Methods The EnVision immunohistochemistry system was used to detect the expression of CXCR1 and CXCR2 in 28 specimens from normal tissues adjacent to breast cancer,30 specimens of invasive ductal carcinoma not otherwise specified (IDC-NOS),and 34 TNBC specimens.The relationship between the expression of CXCR1 and CXCR2,and clinical pathological features was analyzed.Results In the adjacent normal tissues of breast cancer,the positive expression rates of CXCR 1 and CXCR2 were 89.3％ and 92.9％,respectively;CXCR1 and CXCR2 expression displayed no significant association with clinicopathological parameters such as age,tumor size,or Scarff-Bloom-Richardson (SBR) score.The positive expression rates of CXCR1 and CXCR2 were 63.3％ and 60.0％,respectively,in the IDC-NOS samples and 23.5％ and 35.3％,respectively,in the TNBC samples.There was a positive correlation between CXCR1 and CXCR2 expression in the TNBC samples (r =0.606,P ＜ 0.001).Conclusion Correlation of CXCR1 and CXCR2 expression with sample type was strong in adjacent normal tissues,moderate in IDC-NOS samples,and low in TNBC samples.CXCR1 expression was positively correlated with CXCR2 expression in all sample types.The expression of CXCR1 or CXCR2 was closely related to the development and promotion of TNBC.
