OPG and RANKL expression in alveolar bone of type 2 diabetic rats with periodontitis
10.3969/j.issn.1001-3733.2017.05.008
- VernacularTitle:OPG、RANKL在2型糖尿病伴牙周炎大鼠牙槽骨中的表达
- Author:
Wenyi ZHONG
1
;
Kun YANG
;
Li GAO
;
Mengxue YANG
;
Wen'an XIANG
;
Qi LIU
Author Information
1. 遵义医学院附属口腔医院预防儿童牙科
- Keywords:
Periodontitis;
Type 2 diabetes mellitus;
Type 2 diabetic rats with periodontitis;
Receptor activator of nuclear factor-κB ligand;
Osteoprotegerin
- From:
Journal of Practical Stomatology
2017;33(5):607-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) in type 2 diabetic rats with periodontitis.Methods:46 male Wistar rats were randomly divided into the healthy group(n =10),the periodontitis group(n =12),the type 2 diabetes mellitus group(n =12) and the type 2 diabetic periodontitis group(n =12).Animal models were prepared respectively.The expression of OPG and RANKL protein in alveolar bone was detected by immunohistochemistry(IHC).Results:Compared with the healthy group,the expression of OPG in the type 2 diabetes mellitus group,the periodontitis group,the type 2 diabetes mellitus with periodontitis group decreased in turn,however the expression of RANKL increased in turn.The expression of OPG and RANKL had no significant difference between periodontitis group and type 2 diabetes periodontitis group,while there was statistically significant difference among the other groups (P ＜ 0.05).Conclusion:Inflammation may lcad to upregulation of RANKL in osteoclasts and immune cells,and downregulation of OPG in osteoblasts.
