The biological safety and biocompatibility evaluation of the mixture of Paris polyphylla-chitosan for denture adhesive
10.3969/j.issn.1001-3733.2017.05.010
- VernacularTitle:七叶一枝花-壳聚糖混合物作为义齿稳固剂的生物安全性及生物相容性研究
- Author:
Yalin ZHANG
1
;
He MENG
;
Jinyuan LI
;
Wenhui WU
;
Ruiying LIANG
Author Information
1. 华北理工大学口腔医学院修复教研室
- Keywords:
Paris polyphylla;
Chitosan;
Biological safety;
Biocompatibility;
Denture adhesive cream
- From:
Journal of Practical Stomatology
2017;33(5):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the biological safety and biocompatibility of the mixture of Paris polyphylla-chitosan.Methods:According to the GB/T 16886.12-2005 standard,YY/T 0279-1995 standard and GBT16886.5-2003 standard,samples were prepared and tested by oral mucous membrane irritation test,cytotoxicity test and flow cytometry.Results:No local response to the mixture of Paris polyphylla-chitosan was found,and the visual observation and pathological findings of oral mucosa were normal and similar to that of the control group.Therefore,the mixture of Paris polyphylla-chitosan had no irritation response to oral mucosa.The mixture of Paris polyphylla-chitosan showed no cytotoxicity to L929 cells,and did not affect the cycle distribution and apoptosis of L929 cells.Conclusion:The mixture of Paris polyphylla-chitosan has good bio-safety and biocompatibility.
