New topic of complement and diseases
10.3760/cma.j.issn.1009-9158.2017.09.001
- VernacularTitle:补体与疾病:老话题,新契机
- Author:
Ying TAN
1
;
Feng YU
Author Information
1. 100034,北京大学第一医院肾内科
- Keywords:
Complement activation;
Hemoglobinuria,paroxysmal;
Atypical hemolytic uremic syndrome;
Glomerulonephritis
- From:
Chinese Journal of Laboratory Medicine
2017;40(9):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Complement system is involved in the pathogenesis of a group of diseases and also provides an important interface between the innate and adaptive immune response.Currently available tools provide an exciting opportunity to study this system,and some diseases were found to be resulted from excessive and uncontrolled activation of the complement of which the pathogenesis used to be unclear,such as paroxysmal nocturnal hemoglobinuria (PNH),atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G),etc.Several complement inhibitors have been approved for clinical use,and additional complement inhibitory drugs are in development.The use of these drugs in patients will expand our understanding of the benefits and limitations of complement inhibition in human diseases.
