Expression of BAG3 protein in colon cancer tissue detected by tissue microarray method and its clinical significance
10.13481/j.1671-587x.20170620
- VernacularTitle:组织芯片技术检测BAG3蛋白在结肠癌组织中的表达及其临床意义
- Author:
Yansha CAO
1
;
Hua LI
;
Minghong CHEN
;
Baoqin LIU
;
Huaqin WANG
;
Ning LI
Author Information
1. 锦州医科大学生物化学教研室
- Keywords:
colorectal neoplasm;
Bcl related anti-apoptotic protein 3;
tissue microarray;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2017;43(6):1177-1181,后插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of Bcl related anti-apoptotic protein 3 (BAG3 protein)in colon cancer and its clinical significance,and to clarify the relationship between its expression and the occurrence and development of colon cancer.Methods:A total of 90 cases of colon cancer tissue and paracancerous tissue were selected, the expressions of BAG3 protein in different tissues were detected by tissue microarray and immunohistochemical SP method;Kaplan-Meier method,univariate analysis and multivariate analysis were used to investigate the relationship between the clinicopathological parameters and the prognosis of the patients with colon cancer.Results:The expression of BAG3 protein in the colon cancer tissue was high,and the positive expression rates of BAG3 protein in the colon cancer tissue and paracancerous tissue were 37.8% and 0.01%,respectively, and the difference was significant (P < 0.05).The expression of BAG3 protein was associated with gender and tumor size (P <0.05),but there was no correlation between the expression of BAG3 protein in the colon cancer tissue and age,pathologic grade,TNM stage,and lymph node metastasis (P >0.05).The Kaplan-Meier results showed that the expression of BAG3 protein in the colon cancer tissue was not related with the prognosis of the patients and the survival rates of the younger patients and the higher TNM staging patients were high. Conclusion:The expression of BAG3 protein in the colon cancer tissue is high,and its expression is associated with the tumor size;BAG3 protein may act as a tumor marker and therapeutic target for colon cancer.
