Application of detection of serum pepsinogen,gastrin-17 and Helicobacter pylori antibody in gastric cancer screening
10.13481/j.1671-587x.20170621
- VernacularTitle:血清胃蛋白酶原、胃泌素17和幽门螺杆菌抗体检测在胃癌筛查中的应用
- Author:
Gang LIU
1
;
Minxue ZHAO
;
Desheng WANG
Author Information
1. 吉林医药学院附属医院检验科
- Keywords:
pepsinogen;
gastrin-17;
Helicobacter pylori antibody;
stomach neoplasms
- From:
Journal of Jilin University(Medicine Edition)
2017;43(6):1182-1185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of detection of serum pepsinogen (PG),gastrin-17 (G-17) and Helicobacter pylori antibody (anti-HP)in the gastric cancer screening,and to elucidate its clinical value. Methods:A total of 208 patients with early gastric cancer were selected as observation group;at the same time, 208 healthy examinees were regarded as blank control group.The levels of PGⅠ,PGⅡ and G-17 of the subjects in two groups were detected by enzyme-linked immunosorbent assay and latex-enhanced immunoturbidimetry;the positive rates of anti-HP were detected by 13 C urea breath test;the serum levels of PG Ⅰ,PG Ⅱ and PG Ⅰ /PGⅡ ratio of the anti-HP positive subjects (anti-HP positive group)and anti-HP negative subjects (anti-HP negative group)were compared and analyzed.Results:Compared with blank control group,the serum PGⅠ / PGⅡ ratio and PGⅠ level of the subjects in observation group were significantly decreased (P <0.01),and the levels of PG Ⅱ,G-17 and the positive rate of anti-HP were increased (P <0.01).Compared with anti-HP negative group,the serum PGⅠ / PGⅡ ratio and PGⅠ level of the subjects in anti-HP positive group were significantly decreased (P <0.01).The levels of PGⅡ and G-17 were significantly increased (P < 0.01).Conclusion:The detection of positive rate of anti-HP combined with the ratio of PGⅠ /PGⅡ has important clinical significance in gastric cancer screening.The levels of G-17 and PG Ⅱ in the epithelial neoplasia lesion tissue can be used as indicators of gastric precancerous lesions.
