Effect of sleep deprivation on learning and memory network in healthy adults by fMRI
10.19405/j.cnki.issn1000-1492.2017.09.018
- VernacularTitle:睡眠剥夺对健康成人学习记忆网络影响的功能磁共振研究
- Author:
Jiyuan LI
1
;
Yunlong SONG
;
Jianlin QI
Author Information
1. 安徽医科大学
- Keywords:
sleep deprivation;
hippocampus;
resting-state functional magnetic resonance imaging;
functional connectivity
- From:
Acta Universitatis Medicinalis Anhui
2017;52(9):1335-1340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the neural mechanism of learning and memory network disturbance induced by 36 hours sleep deprivation(SD).Methods 18 young male healthy volunteers were enrolled in this study.Resting state functional magnetic imaging(rs-fMRI) data was collected by blood oxygen level dependence functional magnetic imaging(BOLD-fMRI) during rest wakefulness(RW) and 36 hours SD.Bilateral hippocampus were selected as seed points by REST software automated anatomical labeling template.And then compared the differences of functional connectivity(FC) between bilateral hippocampus and whole brain regions by using paired-t test within statistical parametric mapping 8 (SPM8) software.Finally,correlation analysis had been done between significant FC of brain regions and WMS MQ values (SD-RW).Results Compared with RW,the bilateral hippocampus showed positive connected with the right dorsal posterior cingulate cortex,and showed negative functional connectivity with bilateral postcentral gyrus.The WMS MQ was significantly decreased after 36 hours SD.The connection between bilateral hippocampus and the right posterior cingulate cortex showed negative correlation with the deductionofWMS MQ (left:r=-0.463,P=0.015;right:r=-0.546,P=0.003).Conclusion SD has a significant effect on bilateral hippocampal FC.The FC between bilateral hippocampus and right dorsal posterior cingulate cortexis significant increased,while between bilateral postcentral gyrus is decreased after 36 hours SD.The former may be an important neurological mechanism in learning and memory ability regulation after 36 hours sleep deprivation.
