Relationship between Prognosis and Level of Plasma OX40L in Patients with Stable Angina Pectoris after Percutaneous Coronary Intervention
10.12007/j.issn.0258-4646.2017.07.017
- VernacularTitle:稳定型心绞痛患者经皮冠状动脉介入治疗后血浆OX40L水平与预后的关系
- Author:
Hui WANG
1
;
Yang YANG
;
Ping XU
;
Wanliang WANG
;
Qiuhong DU
;
Wenling SONG
;
Qiuyan DUAN
Author Information
1. 沈阳医学院附属第二医院心内科
- Keywords:
OX40L;
stable angina pectoris;
percutaneous coronary intervention;
prognosis
- From:
Journal of China Medical University
2017;46(7):649-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the ehanges in plasma OX40L level in patients with stable angina pectoris (SAP) after percutaneous coronary intervention (PCI) and to investigate the relationship between OX40L level and prognosis in patients with SAP.Methods We collected 200 cases of SAP after PCI.Plasma OX40L levels were examined at different time points,including before and after stent placement,in all patients withSAP.The patients with SAP were followed up for 18 months,and the end point was adverse cardiovascular events.Results The plasma OX40L level increased more apparently after PCI than before PCI (P ＜ 0.05) and peaked at 24 hours.We followed up 185 patients successfully,including 39 (21.08％) patients with and 146 (78.92％) without adverse cardiovascular events.The mean maximum OX40L level was higher in patients with than in those without adverse events (P ＜ 0.05).Multivariable logistic regression analysis revealed that the mean maximum OX40L level was related to adverse cardiovascular events (P ＜ 0.05).Conclusion PCI may cause upregulation of plasma OX40L expression.Mean maximum OX40L level showed good clinical predictive value of occurrence of cardiovascular events 18 months after PCI.
