Effectiveness evaluation on percutaneous vertebroplasty combined with 125 I radioactive particle implantation in treatment of vertebral metastasis
10.13481/j.1671-587x.20170632
- VernacularTitle:经皮椎体成形术联合125I放射粒子植入术治疗椎体转移瘤的效果评价
- Author:
Junchen WANG
1
;
Wei HU
;
Xinlin YU
;
Yuechun LI
;
Haiguo GUO
;
Zhijun FENG
Author Information
1. 西北民族大学第二临床医学院介入医学与肿瘤科
- Keywords:
pereutaneous vertbroplasty;
iodine-125 (125I)radioactive particle;
vertebral metastasis;
numerical rating scale
- From:
Journal of Jilin University(Medicine Edition)
2017;43(6):1243-1247
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the clinical effect of pereutaneous vertbroplasty (PVP) combined with implantation of iodine-125 (125 I)radioactive particle in the treatment of vertebral metastasis,and to provide basis for the treatment of vertebral metastasis.Methods:A total of 69 patients with vertebral metastasis were divided into test group (n=32)and control group (n=37);the patients in test group were treated with PVP comined with implantation 125 I radioactive particle and the patients in control group were treated with PVP only.The heights of anterior and posterior vertebral bodies of the patients before and after treatment were detected by X-ray.The numerical rating scale (NRS)scores,pain relief rate and the incidence of surgical complications of the patients were recorded before operation and 1 d,1 week,1 month,3 months,and 6 months after operation.Results:The operation was successfully performed in all the patients without local bleeding;there were no movement dysfunction and nerve compression phenomenon.There was no leakage of bone cement.All the 125 I radioactive particles located well and there was no particle obscission.The heights of vertebral bodies of the patients in two groups after operation were increased compared with before operation (P <0.05).The NRS scores of the patients in two groups s at 1 d,1 week,1 month,3 months,6 months after operation were significantly decreased compared with before operation (P <0.05);compared with control group,the NRS scores of the patients in test group at 1 d,1 week, 1 month,3 months,6 months after operation were decreased (P <0.05).The incidence of pulmonary embolism or radiation myelitis complications was about 4.3% in 69 patients.Compared with control group,the difference in the incidence of complications of the patients in test group was not significant (P < 0.05 ).Conclusion:PVP combined with 125 I radioactive particle implantation is a safe and effective method in the treatment of vertebral metastasis,which can relieve the pain of the patients obviously compared with PVP.
