Insertion of biodegradable silicon-covered magnesium alloy stent in esophagus, a preliminary in vitro and in vivo study of feasibility and tissue reaction in experimental rabbits
10.3969/j.issn.1008-794X.2017.09.012
- VernacularTitle:硅膜-镁合金可降解支架置入兔食管可行性及组织反应——外和体内初步研究
- Author:
Kai YANG
1
;
Yueqi ZHU
;
Tianwen YUAN
;
Geng ZHOU
;
Wenguo CUI
;
Yingsheng CHENG
Author Information
1. 200233,上海交通大学附属第六人民医院影像科
- Keywords:
biodegradable stent;
magnesium alloy;
esophagus;
tissue reaction;
in vivo and in vitro experiment
- From:
Journal of Interventional Radiology
2017;26(9):816-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanical properties and degradation behavior of biodegradable silicon-covered magnesium alloy stent in vitro,to investigate the technical feasibility of its implantation into rabbit esophagus and to observe the tissue reaction in vivo.Methods The mechanical compression recovery properties and the degradation behavior of biodegradable silicon-covered magnesium alloy stent were tested in vitro.A total of 30 healthy Holland rabbits were randomly divided into silicon-covered magnesium alloy stent group (n=15) and control group (n=15).For rabbits in the silicon-covered magnesium alloy stent group fluoroscopy-guided insertion of the stent into the lower third segment of esophagus was conducted,while for rabbits in the control group no intervention was adopted.One,2 and 4 weeks after the implantation of the stent,esophagography was performed for all rabbits of both groups,and each time every 5 rabbits from both groups were sacrificed,the specimens were collected and sent for histological examinations.Results In vitro test indicated that biodegradable silicon-covered magnesium alloy stent had good flexibility and elasticity,and in phosphate-buffered saline with pH 4.0 or pH 7.4 it degraded more slowly than bare magnesium alloy stent.In vivo test showed that the stent implantation could be well tolerated by all experimental rabbits.Before stent insertion the esophageal diameter was(9.2±0.8) mm,and at one,2 and 4 weeks after stent insertion the esophageal diameters were (9.7±0.7) mm,(9.6±0.8) mm and (9.6±0.5) mm respectively (P＞0.05).In the silicon-covered magnesium alloy stent group,stent displacement occurred in 6 rabbits in one week (n=l),2weeks (n=1) and 4 weeks (n=4).After stent implantation,the tissue reactions such as esophageal wall injury,collagen deposition,etc.were not obviously different from those in the control group (P＞0.05).Conclusion It is technically feasible to insert silicon-covered magnesium alloy stent into the rabbit's esophagus,the stent can provide sufficient support for at least 2 weeks,the stent displacement rate is low and acceptable,and no severe esophageal wall injury and collagen deposition are observed.
