Diagnostic value of procalcitonin for articular infection in adults: a meta-analysis
10.3969/j.issn.2095-4344.2017.31.027
- VernacularTitle:降钙素原诊断成人骨关节感染的Meta分析
- Author:
ting Ting WANG
1
;
peng Wei SUN
;
Shuang LIANG
;
yu Gui ZHANG
;
Chi ZHOU
;
ling Mei ZHU
Author Information
1. 广州中医药大学附属宝安中医院
- From:
Chinese Journal of Tissue Engineering Research
2017;21(31):5078-5084
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Due to special physiological characteristics, articular infection is difficult to be cured successfully. Early diagnosis is critical for the treatment of articular infection, thereafter, searching for a biomarker with high sensitivity and specificity is necessary.OBJECTIVE: To systematically evaluate the value of procalcitonin for diagnosing joint infection in adult.METHODS: A computer-based online research was performed for the literature in PubMed, EMbase, the Cochrane Library and CNKI databases from 1990 to June 2017. Literature screening and data extraction were conducted by two reviewers independently according to the inclusion and exclusion criteria. The risk of bias of included studies was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2. Meta-analysis was then performed using Stata 14.0 software. The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were calculated; the summary receiver operating characteristic curve was drawn and the area under the curve was calculated.RESULTS AND CONCLUSION: (1) A total of 10 studies were included, involving 893 patients. (2) The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of procalcitonin diagnosing joint infection were 0.82 (95%CI=0.72-0.89), 0.89 (95%CI=0.82-0.93), 7.20 (95%CI=4.6-11.3), 0.20 (95%CI=0.13-0.32), 35 (95%CI=18-71) and 0.92 (95%CI=0.90-0.94), respectively. (3) To conclude, procalcitonin exhibits more diagnostic efficiency for assessing articular infection in adults.
