Physiological functions of Ets family of transcription factors
10.3969/j.issn.1001-1978.2017.12.005
- VernacularTitle:Ets转录因子的生理作用研究进展
- Author:
Hong ZENG
1
;
Yang YANG
;
Shu AN
;
xi Xiao GUO
;
Qian HAO
;
rui Tian XU
;
Ying LIU
Author Information
1. 昆明理工大学生命科学与技术学院细胞信号传导实验室
- Keywords:
Ets transcription factors;
embryonic development;
growth;
differentiation;
apoptosis;
tumor;
physiological function
- From:
Chinese Pharmacological Bulletin
2017;33(12):1645-1650
- CountryChina
- Language:Chinese
-
Abstract:
Ets is one largest family of the transcription factors with complex structure and function of all family members. They play an important role in the regulation of many physiological and pathological processes through regulating embryonic develop-ment,cell growth,differentiation,cell apoptosis and interac-tions of cells under the regulation of MAP kinases(ERK,p38 and JNK),Ca2 + relevant signaling pathways and TGF-β path-ways. Notably,many Ets members involve in tumor genesis,in-vasion and metastasis,and these members may be markers of anticipating tumor genesis,development and prognosis. Here the physiological role of Ets family members and its relationship with human diseases are summarized,aiming to provide a theoretical basis for the study of the role of Ets family in human diseases.
