Research progress of hepatocyte necroptosis in liver injuries
10.3969/j.issn.1001-1978.2017.12.006
- VernacularTitle:肝细胞程序性坏死在肝损伤中的研究进展
- Author:
Yan JIA
1
;
huan Huan JIN
;
meng Meng LI
;
Ling WANG
;
xia Fei WANG
;
xi Chen ZHANG
;
Feng ZHANG
;
zhong Shi ZHENG
Author Information
1. 南京中医药大学江苏省中药药效与安全性评价重点实验室
- Keywords:
necroptosis;
hepatocyte;
liver injury;
alcoholic fatty liver;
nonalcoholic fatty liver;
liver fibrosis
- From:
Chinese Pharmacological Bulletin
2017;33(12):1651-1655
- CountryChina
- Language:Chinese
-
Abstract:
Various pathological factors can result in the death of hepatocytes during liver injury. Persistent hepatocyte death initi-ates and aggravates chronic inflammation and fibrosis,ultimately leading to liver cirrhosis and hepatocellular carcinoma. Thus, limiting hepatocyte death is an effective strategy for improving liver injury. Necroptosis is a newly characterized form of cell death,which is highly regulated by signaling pathways and has typical morphological features of necrosis. Increasing evidence indicates that necroptosis plays a key role in drug-induced or im-munological acute liver injuries,and in chronic liver injuries in-cluding alcoholic fatty liver,nonalcoholic fatty liver and liver fi-brosis. This article reviews the recent advances on the hepato-cyte necroptosis in liver injury,providing novel insights into the pathogenesis of liver disease and related therapeutic reagents.
